Features

 

LTQ-Orbitrap Velos Pro with ETD from Thermo-Fisher Scientific with TriVersa NanoMate from Advion or Ultimate 3000 RSLCnano HPLC from Dionex

• ESI Chip of the TriVersa consists of an array of 400 nanoelectrospray emitters with different inner diameters allowing for flow rates of 20 to 300 nL/min.
• Nozzles on the ESI Chip provide a long, stable spray, and in infusion mode, eliminate sample-to-sample carryover.
• TriVersa can be used for Chip-based infusion or LC/MS fraction collection
• TriVersa can be coupled to any conventional HPLC system for MS analysis
• Higher pressure capability of the RSLCnano platform allows the use of longer columns and/or columns packed with smaller particles for higher resolution separations of complex (digested) protein samples
• Temperature-controlled column compartment for maintaining exceptional retention time reproducibility
• LTQ-Orbitrap Velos Pro has resolution of 60,000 at m/z 400 at a scan rate of 1Hz
• Mass accuracy of < 3 ppm with external calibration
• Equipped with HCD cell for more efficient quantitation of isobarically labeled peptides
• Equipped with Electron Transfer Dissociation (ETD) to generate complementary information for highly sensitive PTM analyses and de novo sequencing
• Parallel MS and MSn analysis



Q-Exactive from Thermo-Fisher Scientific with TriVersa NanoMate from Advion,  2DLC Ultra nanoLC from Eksigent or 1200 capillaryLC from Agilent

 • ESI Chip of the TriVersa consists of an array of 400 nanoelectrospray emitters with different inner diameters allowing for flow rates of 20 to 300 nL/min.
• Nozzles on the ESI Chip provide a long, stable spray, and in infusion mode, eliminate sample-to-sample carryover.
• TriVersa can be used for Chip-based infusion or LC/MS fraction collection
• TriVersa can be coupled to any conventional HPLC system for MS analysis
• The variety of HPLCs that can be coupled to the Q-Exactive allows for nano-capillary separations of proteins and peptides where sample is limiting to small molecule analysis on standard analytical scale chromatography
• Q-Exactive has resolution of ~50,000 at m/z 400 at a scan rate of 1Hz
• Mass accuracy of < 5 ppm with external calibration
• Equipped with HCD cell for more efficient quantitation of isobarically labeled peptides
• Scan range of m/z 50-600 for analysis of small molecules to intact natively folded proteins
• Capable of parallel SIM or MS/MS scans for increased sensitivity and decreased cycle time


6500 QTRAP with SelexION from AB SCIEX with microLC from Eksigent

​• SelexION feature allows resolution of isobaric species using differential mobility spectrometry
• MicroLC can utilize 0.3 to 2 mm ID columns and operate at up to 10,000 PSI
​• Up to 100 fold more sensitive than previous generation LC-MS/MS systems
• Enables high-sensitivity full-scan MS, MS/MS, and MS3 with high-selectivity from true triple   quadrupole precursor ion (PI) and neutral loss (NL) scans.
• Perform multiple reaction monitoring (MRM) for quantitation using high-sensitivity triple quadrupole.
• Identify, characterize, and quantitate metabolites quickly and easily.


5975C GC-MS from Agilent

​• Inert ion source-now programmable up to 350˚C

• Triple-Axis HED-EM Detector

 

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ITQ-900 GC-MS/MS/FID from Thermo-Fisher Scientific

​​• Ion-trap mass spectrometer capable of MS/MS for structure verification/elucidation

• FID detector on the same instrument for parallel analyses

 


Trace GC-FID from Thermo-Fisher Scientific

• GC-FID great for quantitative analysis such as FAMEs etc.


 

 

MASCOT Search Engine from Matrix Science

• A powerful database search engine
• Integrates all the proven methods of database searching
• Peptide Fingerprint, Sequence Query and MS/MS Ion Search
• Total flexibility in chemical/post-translational modifications 

  
 

Scaffold from Proteome Software

• MS/MS analysis & visualization software
• See proteins identified across multiple samples.
• Combine Sequest and Mascot scores for increased confidence.
• Get more detailed and accurate information from your MS/MS experiments



   

ACQUITY UPLC System from Waters

• Reliable, high quality chromatographic separations produced up to 10 times faster than current HPLC methods, reducing time and cost per sample.
• Increased efficiency for sharper peaks and better resolution, resulting in better quantitative and qualitative analyses.




  
     

Agilent 3100 OFFGEL Fractionator

• pI-based OFFGEL fractionation with 0.1 – 0.6 pH resolution depending on consumable kit  used
• In-solution fraction recovery for easy transfer to LC/MS Up to 16 samples fractionated at the same time
• µg to mg load capacity

   


 

TissueLyser II